2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

Base Information

Chemical Name:2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one
CAS No.:1353948-60-3
Molecular Formula:C₂₇H₂₅F₂NO₄
Molecular Weight:465.497
Hs Code.:

Synonyms:2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

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Chemical Property of 2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

Chemical Property:

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Technology Process of 2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

There total 7 articles about 2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1353948-59-0
(S)-2-chloro-7-(2,2-dimethyl-[1,3]dioxolan-4-yl)methoxy-10,11-dihydrodibenzo[a,d]cyclohepten-5-one

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1353948-60-3
2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

Guidance literature:: With palladium diacetate; sodium t-butanolate; XPhos; In toluene; tert-butyl alcohol; at 90 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm300327h

Reference yield: 68.0%

: 1353948-60-3
2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

Guidance literature:

Reference yield:

: 4741-63-3
6-methoxyphthalide

: 1353948-60-3
2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 85 - 112 °C

2.1: triphenylphosphine / methanol / 2 h / Reflux

2.2: 3.75 h / 0 °C

3.1: palladium on activated charcoal; hydrogen / ethyl acetate; acetonitrile / 5 h / 20 °C

4.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

4.2: 1.5 h / 20 °C

5.1: hydrogen bromide; acetic acid / water / 0.75 h / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere

7.1: palladium diacetate; sodium t-butanolate; XPhos / toluene; tert-butyl alcohol / 2 h / 90 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen bromide; hydrogen; palladium diacetate; potassium carbonate; acetic acid; triphenylphosphine; sodium t-butanolate; XPhos; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; toluene; acetonitrile; tert-butyl alcohol; 2.2: Wittig reaction / 4.2: Friedel Crafts reaction / 7.1: Buchwald-Hartwig reaction;
DOI:10.1021/jm300327h