Technology Process of Skepinone-L
There total 4 articles about Skepinone-L which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one;
With
water; toluene-4-sulfonic acid;
In
methanol;
at 50 ℃;
for 6h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen bromide / acetic acid / 5 h / 100 °C
2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere
With
hydrogen bromide; potassium carbonate;
In
acetic acid; N,N-dimethyl-formamide;
DOI:10.3390/molecules27010203
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate / methanol / 10 h / 70 °C / Cooling with ice
2.1: palladium 10% on activated carbon / ethyl acetate; acetonitrile / 12 h / 20 °C
3.1: thionyl chloride / dichloromethane / 1 h / 40 °C
3.2: 3 h / 20 °C
4.1: potassium tert-butylate; palladium diacetate; XPhos / toluene; tert-butyl alcohol / 24 h / 110 °C / Inert atmosphere
5.1: hydrogen bromide / acetic acid / 5 h / 100 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere
With
thionyl chloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen bromide; sodium methylate; palladium diacetate; potassium carbonate; XPhos;
In
methanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.3390/molecules27010203
