N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane

Base Information

• Chemical Name: N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane
• CAS No.: 851219-20-0
• Molecular Formula: C₅₀H₇₉N₃O₁₂
• Molecular Weight: 914.19

Synonyms:N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane

Chemical Property of N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane

Chemical Property:

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Technology Process of N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane

There total 6 articles about N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N1-cholesteryloxycarbonyl-3-aza-N3-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-hydroxytetradecane (851219-19-7) + 4-Nitrophenyl chloroformate (7693-46-1) → N1-cholesteryloxycarbonyl-3-aza-N3-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O15-4''-nitrophenyloxycarbonyltetradecane (851219-20-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 10h;

DOI:10.1039/b418168a

Reference yield:

N1-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane (851219-16-4) → N1-cholesteryloxycarbonyl-3-aza-N3-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O15-4''-nitrophenyloxycarbonyltetradecane (851219-20-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / diphenyl 2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH₂Cl₂ / 20 °C

2: 74 percent / Na; naphthalene / tetrahydrofuran / 0.75 h / -30 °C

3: 84 percent / Et₃N / CH₂Cl₂ / 10 h

4: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 10 h

With dmap; naphthalene; 2-(diphenylphosphino)pyridine; di-tert-butyl-diazodicarboxylate; sodium; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/b418168a

Reference yield:

N1-cholesteryloxycarbonyl-3-aza-6,9,12-trioxa-1-amino-15-hydroxytetradecane (851219-18-6) → N1-cholesteryloxycarbonyl-3-aza-N3-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O15-4''-nitrophenyloxycarbonyltetradecane (851219-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 10 h

2: 92 percent / Et₃N; DMAP / CH₂Cl₂ / 10 h

With dmap; triethylamine; In dichloromethane;

DOI:10.1039/b418168a

upstream raw materials:

N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-hydroxytetradecane

4-Nitrophenyl chloroformate

N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane

N¹-cholesteryloxycarbonyl-3-aza-6,9,12-trioxa-1-amino-15-hydroxytetradecane

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