1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea
CAS No.:1429397-32-9
Molecular Formula:C₂₉H₂₈ClFN₆O₃S
Molecular Weight:595.097
Hs Code.:

Synonyms:1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

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Chemical Property of 1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

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Technology Process of 1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

There total 3 articles about 1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1341216-05-4
1-cyclopropyl-3-(3-fluoro-4-((2-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)urea

: 79-04-9
chloroacetyl chloride

: 1429397-32-9
1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: With triethylamine; In dichloromethane; at -5 - 20 ℃; Inert atmosphere;

Reference yield:

: 1341216-04-3
tert-butyl 4-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]-pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

: 1429397-32-9
1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: triethylamine / dichloromethane / -5 - 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429397-32-9
1-(4-((2-(5-((4-(2-chloroacetyl)piperazin-1-yl)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.25 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: triethylamine / dichloromethane / -5 - 20 °C / Inert atmosphere

With acetic acid; triethylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane;