1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester

Base Information

• Chemical Name: 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester
• CAS No.: 170750-37-5
• Molecular Formula: C₃₄H₃₆FNO₇
• Molecular Weight: 589.661
• Mol file: 170750-37-5.mol

Synonyms:1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester

Chemical Property of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester

There total 3 articles about 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

1-(3-bromopropoxy)-4-fluorobenzene (1129-78-8) + 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester (170750-35-3) → 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester (170750-37-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

DOI:10.1248/cpb.43.818

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester (170750-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine, acetic acid / benzene / 2 h / Heating

2: triethylamine / benzene / 3 h / Heating

3: 29 percent / NaH / dimethylformamide / 4 h / 100 °C

With piperidine; sodium hydride; acetic acid; triethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.43.818

Reference yield:

2-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid benzyl ester (1026584-12-2) → 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluoprophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester (170750-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / benzene / 3 h / Heating

2: 29 percent / NaH / dimethylformamide / 4 h / 100 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.43.818

upstream raw materials:

1-(3-bromopropoxy)-4-fluorobenzene

1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl-5-benzylester

3,4-dimethoxy-benzaldehyde

2-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid benzyl ester

Downstream raw materials:

1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-<3-(4-fluorophenoxy)propyl>-3,5-pyridinedicarboxylic acid 3-methylester