tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

Base Information

Chemical Name:tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate
CAS No.:1287206-15-8
Molecular Formula:C₁₆H₂₅BrN₂O₃
Molecular Weight:373.29
Hs Code.:

Synonyms:tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

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Chemical Property of tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

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Technology Process of tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

There total 5 articles about tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: (2S,3R)-2-(Boc-amino)-3-methoxybutyric acid 4-bromophenylamide

: 1287206-15-8
tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 - 65 ℃; for 48.5h;
DOI:10.1021/acs.jmedchem.8b00566

Reference yield:

: 1287206-14-7
((1S,2R)-1-formyl-2-methoxypropyl)carbamic acid tert-butyl ester

: 106-40-1
4-bromo-aniline

: 1287206-15-8
tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

Guidance literature:: ((1S,2R)-1-formyl-2-methoxypropyl)carbamic acid tert-butyl ester; 4-bromo-aniline; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In 1,2-dichloro-ethane;

Reference yield:

: 48068-25-3,1396972-31-8
(2S,3R)-2-((tert-butoxycarbonyl)amino)-3-methoxybutanoic acid

: 1287206-15-8
tert-butyl {(2R,3R)-1-[(4-bromophenyl)amino]-3-methoxybutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / 1,2-dichloro-ethane / 0.02 h / -15 °C

2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 5 h / 20 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

With 4-methyl-morpholine; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;