6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

Base Information

Chemical Name:6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate
CAS No.:1307381-93-6
Molecular Formula:C₂₇H₄₁NO₇
Molecular Weight:491.625
Hs Code.:

Synonyms:6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

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Chemical Property of 6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

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Technology Process of 6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

There total 4 articles about 6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307381-95-8
ethyl 5-(benzyloxy)-2-(diethoxyphosphoryl)pentanoate

: 81323-59-3
tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoate

: 1307381-93-6
6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

: 1307381-94-7
6-tert-butyl 1-ethyl (2E,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

Guidance literature:: ethyl 5-(benzyloxy)-2-(diethoxyphosphoryl)pentanoate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoate; In tetrahydrofuran; at 0 ℃; for 1.5h;

Reference yield:

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 1307381-93-6
6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

: 1307381-94-7
6-tert-butyl 1-ethyl (2E,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 2.33 h / 20 °C / Inert atmosphere

1.2: 14 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

With sodium hydride; In tetrahydrofuran;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1307381-93-6
6-tert-butyl 1-ethyl (2Z,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

: 1307381-94-7
6-tert-butyl 1-ethyl (2E,5S)-2-[3-(benzyloxy)propyl]-5-[(tert-butoxycarbonyl)amino]hex-2-enedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane; pyridine / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

With pyridine; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;