2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

Base Information

Chemical Name:2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol
CAS No.:1345686-06-7
Molecular Formula:C₂₅H₂₄N₄O₄
Molecular Weight:444.49
Hs Code.:

Synonyms:2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

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Chemical Property of 2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

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Technology Process of 2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

There total 8 articles about 2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 957063-06-8
(5-bromopyridin-2-yl)-(morpholin-4-yl)methanone

: 1345688-10-9
1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

: 1345686-06-7
2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

Guidance literature:: (5-bromopyridin-2-yl)-(morpholin-4-yl)methanone; 1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole; With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In ethanol; water; at 80 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

Reference yield:

: 1345687-89-9
4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitro-N-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}aniline

: 1345686-06-7
2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; palladium(II) hydroxide / ethanol / 2 h / 20 °C

2.1: ytterbium trifluoromethanesulfonate / 0.17 h / 90 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4.1: pyridine / dichloromethane / -20 - -10 °C

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 0.33 h / 80 °C / Inert atmosphere

6.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water / 1 h / 80 °C / Inert atmosphere

6.2: 2 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ytterbium trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; palladium(II) hydroxide; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 610-81-1
4-hydroxy-2-nitroaniline

: 1345686-06-7
2-(4-{5-[6-(morpholin-4-ylcarbonyl)pyridin-3-yl]-1H-benzimidazol-1-yl}phenoxy)ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / dichloromethane / 20 °C / Cooling with ice

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine / toluene / 0.17 h / 110 °C / Inert atmosphere

3.1: hydrogen; palladium(II) hydroxide / ethanol / 2 h / 20 °C

4.1: ytterbium trifluoromethanesulfonate / 0.17 h / 90 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

6.1: pyridine / dichloromethane / -20 - -10 °C

7.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 0.33 h / 80 °C / Inert atmosphere

8.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water / 1 h / 80 °C / Inert atmosphere

8.2: 2 h / 20 °C

With pyridine; 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ytterbium trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; palladium(II) hydroxide; potassium carbonate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; sodium t-butanolate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;