1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

Base Information

Chemical Name:1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole
CAS No.:1345688-10-9
Molecular Formula:C₂₆H₃₃BN₂O₅
Molecular Weight:464.369
Hs Code.:

Synonyms:1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

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Chemical Property of 1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

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Technology Process of 1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

There total 7 articles about 1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1345687-97-9
1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazol-5-yl trifluoromethanesulfonate

: 73183-34-3
bis(pinacol)diborane

: 1345688-10-9
1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 1345687-93-5
5-{ [tert-butyl(dimethyl)silyl]oxy}-1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-1H-benzimidazole

: 1345688-10-9
1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

2: pyridine / dichloromethane / -20 - -10 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 0.33 h / 80 °C / Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl ammonium fluoride; potassium acetate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1345687-89-9
4-{[tert-butyl(dimethyl)silyl]oxy}-2-nitro-N-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}aniline

: 1345688-10-9
1-{4-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]phenyl}-5-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium(II) hydroxide / ethanol / 2 h / 20 °C

2: ytterbium trifluoromethanesulfonate / 0.17 h / 90 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4: pyridine / dichloromethane / -20 - -10 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 0.33 h / 80 °C / Inert atmosphere

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ytterbium trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; potassium acetate; palladium(II) hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;