tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

Base Information

Chemical Name:tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate
CAS No.:1217796-99-0
Molecular Formula:C₃₃H₄₇FN₂O₉P₂
Molecular Weight:696.69
Hs Code.:

Synonyms:tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

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Chemical Property of tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

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Technology Process of tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

There total 1 articles about tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 94061-83-3
Fluvastatin lactone

: 80474-99-3
tetraethyl (aminomethylene)bis(phosphonate)

: 1217796-99-0
tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 48h;
DOI:10.2174/157017809788681356

Reference yield: 73.6%

: 1217796-99-0
tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate

: N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonic acid tetrasodium

Guidance literature:: tetraethyl N-(((3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl)-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoyl)aminomethylenebisphosphonate; With 2,4,6-trimethyl-pyridine; trimethylsilyl bromide; In dichloromethane; at 0 ℃; for 48h;

With sodium hydroxide; In water; at 20 ℃; for 24h;
DOI:10.2174/157017809788681356