(Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

Base Information

Chemical Name:(Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide
CAS No.:1616111-01-3
Molecular Formula:C₂₂H₂₂N₂O₅
Molecular Weight:394.427
Hs Code.:

Synonyms:(Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

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Chemical Property of (Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

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Technology Process of (Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

There total 10 articles about (Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1616110-80-5
3-oxo-2,3-dihydrobenzofuran-7-carboxamide

: 82625-45-4
4-(2-morpholin-4-yl-ethoxy)-benzaldehyde

: 1616111-01-3
(Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

Guidance literature:: With ammonium acetate; In toluene; for 5h; Reflux;
DOI:10.1021/jm5002502

Reference yield:

: C₁₄H₁₄O₆

: 1616111-01-3
(Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: ammonium acetate / toluene / 5 h / Reflux

With ammonium hydroxide; ammonium acetate; In tetrahydrofuran; toluene;
DOI:10.1021/jm5002502

Reference yield:

: 23287-26-5
3-methylsalicylic acid methyl ester

: 1616111-01-3
(Z)-2-[4-(2-morpholin-4-ylethoxy)-benzylidene]-3-oxo-2,3-dihydrobenzofuran-7-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: potassium hydroxide / methanol / 4 h / Reflux

2.2: 0 °C / pH 1

3.1: potassium permanganate; water / 2 h / Reflux

4.1: acetic anhydride; sodium acetate; acetic acid / 5 h / Reflux

5.1: 4-methyl-morpholine / tetrahydrofuran / 4 h / -20 °C / Inert atmosphere

6.1: ammonium hydroxide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7.1: ammonium acetate / toluene / 5 h / Reflux

With 4-methyl-morpholine; ammonium hydroxide; potassium permanganate; ammonium acetate; water; sodium acetate; acetic anhydride; potassium carbonate; acetic acid; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm5002502