(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate

Base Information

• Chemical Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate
• CAS No.: 170157-72-9
• Molecular Formula: C₁₈H₂₄N₂O₂
• Molecular Weight: 300.401
• Mol file: 170157-72-9.mol

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate

Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate

There total 8 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1R,2S,5R)-Menthyl 2-oxophenylacetate tosylhydrazone (170157-70-7) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate (170157-72-9)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jo00119a023

Reference yield: 92.0%

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-phenylacetate (26171-78-8) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate (170157-72-9)

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo100356d

Reference yield:

(-)-menthol (2216-51-5) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-diazo-2-phenylacetate (170157-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / p-TsOH / toluene / Heating

2: 88 percent / toluene / Heating

3: 99 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;

DOI:10.1021/jo00119a023

upstream raw materials:

(1R,2S,5R)-Menthyl 2-oxophenylacetate tosylhydrazone

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-phenylacetate

(-)-menthol

l-menthyl phenylglyoxylate

Downstream raw materials:

l-menthyl phenylglyoxylate