benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

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Chemical Name:benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate
CAS No.:221077-56-1
Molecular Formula:C₃₉H₄₉N₃O₉
Molecular Weight:703.833
Hs Code.:

Synonyms:benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

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Chemical Property of benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

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Technology Process of benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

There total 5 articles about benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5-((S)-2-Amino-2-pentylcarbamoyl-ethyl)-2-methoxycarbonylmethoxy-benzoic acid benzyl ester

: 221077-56-1
benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Ice cooling;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 221077-56-1
benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 27 percent / Et₃N; 1,1'-bis(diphenylphosphino)ferrocene / palladium(II) acetate / dimethylformamide / 16 h / 70 °C

2: 66 percent / K₂CO₃ / acetone / 50 °C

3: TFA / CH₂Cl₂ / 4 h / 0 - 20 °C

4: 0.46 g / 1-hydroxybenzotriazole; EDC / CH₂Cl₂ / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm011100y

Reference yield:

: 221077-42-5
tert-butyl (1S)-1-(4-hydroxy-3-iodobenzyl)-2-oxo-2-(pentylamino)ethylcarbamate

: 221077-56-1
benzyl 5-[(2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoyl}amino)-3-oxo-3-(pentylamino)propyl]-2-(2-methoxy-2-oxoethoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 27 percent / Et₃N; 1,1'-bis(diphenylphosphino)ferrocene / palladium(II) acetate / dimethylformamide / 16 h / 70 °C

2: 66 percent / K₂CO₃ / acetone / 50 °C

3: TFA / CH₂Cl₂ / 4 h / 0 - 20 °C

4: 0.46 g / 1-hydroxybenzotriazole; EDC / CH₂Cl₂ / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm011100y