benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

Base Information

Chemical Name:benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate
CAS No.:221077-53-8
Molecular Formula:C₂₇H₃₆N₂O₆
Molecular Weight:484.593
Hs Code.:

Synonyms:benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

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Chemical Property of benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

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Technology Process of benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

There total 3 articles about benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 201230-82-2
carbon monoxide

: 100-51-6,185532-71-2
benzyl alcohol

: 221077-53-8
benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

Guidance literature:: With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In DMF (N,N-dimethyl-formamide); at 60 ℃; for 12h;

Reference yield: 27.0%

: 201230-82-2
carbon monoxide

: 100-51-6,185532-71-2
benzyl alcohol

: 221077-42-5
tert-butyl (1S)-1-(4-hydroxy-3-iodobenzyl)-2-oxo-2-(pentylamino)ethylcarbamate

: 221077-53-8
benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 16h; under 760.051 Torr;
DOI:10.1021/jm010393s

Reference yield:

: 71400-63-0,478183-68-5
N-tert-butyloxycarbonyl-3-iodo-L-tyrosine

: 221077-53-8
benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: EDC / CH₂Cl₂ / 16 h / 0 °C

2: 27 percent / Et₃N; Pd(OAc)2; 1,1'-bis(diphenylphosphino)ferrocene / dimethylformamide / 16 h / 70 °C / 760.05 Torr

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010393s