2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

Base Information

Chemical Name:2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester
CAS No.:102977-51-5
Molecular Formula:C₂₅H₂₇N₂O₇PS
Molecular Weight:530.538
Hs Code.:

Synonyms:2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

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Chemical Property of 2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

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Technology Process of 2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

There total 3 articles about 2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 102977-49-1,102977-50-4
2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hex-5'-enofuranosyl>-4-thiazolecarboxamide, diphenyl ester

: 102977-51-5
2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 1h; under 760 Torr;
DOI:10.1021/jm00159a027

Reference yield:

: 60084-11-9
2-(2',3'-O-isopropylidene-β-D-ribofuranosyl)thiazole-4-carboxamide

: 102977-51-5
2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) dicyclohexylcarbodiimide (DCC), Me₂SO, 2.) pyridine / 1.) 18 h, 2.) 36 h

2: 88 percent / H₂ / 5percent Pd/C / methanol / 1 h / 760 Torr

With pyridine; hydrogen; dimethyl sulfoxide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00159a027

Reference yield:

: 22400-41-5
diphenyl [(triphenylphosphoranylidene)methyl]phosphonate

: 102977-51-5
2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) dicyclohexylcarbodiimide (DCC), Me₂SO, 2.) pyridine / 1.) 18 h, 2.) 36 h

2: 88 percent / H₂ / 5percent Pd/C / methanol / 1 h / 760 Torr

With pyridine; hydrogen; dimethyl sulfoxide; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00159a027