60084-11-9

Usage

Uses

Used in Pharmaceutical Industry:
2-[2,3-O-(1-Methylethylidene)-β-D-ribofuranosyl]-4-thiazolecarboxamide is used as an intermediate in the synthesis of Tiazofurin (T437200) for its potential therapeutic applications in cancer treatment. 2-[2,3-O-(1-Methylethylidene)-β-D-ribofuranosyl]-4-thiazolecarboxaMide plays a crucial role in the development of new cancer therapies, as Tiazofurin has shown promise in targeting various types of cancer cells and inhibiting their growth.

Upstream product

• 60084-10-8 tiazofurin 
• 77-76-9 2,2-dimethoxy-propane 
• 60084-09-5 ethyl 2-(2',3',3''-tri-O-benzoyl-β-D-apiofuranosyl)thiazole-4-carboxylate 
• 57944-10-2 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonthioamide 
• 67-64-1 acetone 

Downstream Products

• 102977-57-1 adenosine 5'- 5'<*>5'-ester with 2-β-D-ribofuranosyl-4-thiazolecarboxamide 
• 108311-18-8 2',3'-O-isopropylidene-5'-O-tosyltiazofurin 
• 253682-74-5 {Benzyloxy-[(3aR,4R,6R,6aR)-6-(4-carbamoyl-thiazol-2-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy]-phosphorylmethyl}-phosphonic acid dibenzyl ester 
• 896420-04-5 2-(5-O-benzoyl-2,3-O-isopropylidene-β-D-ribofuranosyl)thiazole-4-carboxamide 
• 83285-83-0 Tiazofurin adenine dinucleotide 
• 102977-51-5 2-<5',6'-dideoxy-2',3'-O-(1-methylethylidene)-6'-phosphono-β-D-ribo-hexofuranosyl>-4-thiazolecarboxamide, diphenyl ester 
• 943980-79-8 C₄₄H₅₅N₉O₁₅S₃ 

Relevant academic research and scientific papers

Synthesis and?biological activity of?some?new 5′-O-acyl tiazofurin derivatives

Three new 5′-O-acyl tiazofurin derivatives 2-4 were synthesized and evaluated for their antiproliferative activity against different tumour cell lines as well as for their ability to induce apoptosis in C6 cells in vitro. Apart of the antitumour assays, t