1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

Base Information

Chemical Name:1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea
CAS No.:1420468-86-5
Molecular Formula:C₂₁H₂₃F₃N₆O₂
Molecular Weight:448.448
Hs Code.:

Synonyms:1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

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Chemical Property of 1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

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Technology Process of 1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

There total 12 articles about 1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1420468-83-2
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

: 1420468-86-5
1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

Guidance literature:: bis(trichloromethyl) carbonate; 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine; With dmap; In dichloromethane; at 0 - 20 ℃;

With ammonia; In dichloromethane; at 0 ℃; for 0.05h;
DOI:10.1021/ml300330m

Reference yield:

: 1420468-30-9
2-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-3-oxobutanenitrile

: 1420468-86-5
1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrazine hydrate / ethanol / 20 - 100 °C / Inert atmosphere

2.1: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

3.1: N,N-diethylaniline; trichlorophosphate / 3.25 h / 0 - 80 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran / 3 h / 50 °C

5.1: ethanol / 3 h / 145 °C / Microwave irradiation

6.1: N,N-diethylaniline; trichlorophosphate / 0.58 h / 0 - 80 °C / Inert atmosphere

7.1: ammonia / methanol / 3 h / 0 - 135 °C / Inert atmosphere

8.1: dmap / dichloromethane / 0 - 20 °C

8.2: 0.05 h / 0 °C

With dmap; ammonia; sodium methylate; hydrazine hydrate; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ml300330m

Reference yield:

: 1420468-78-5
7-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidine

: 1420468-86-5
1-(2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-5-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / methanol / 3 h / 0 - 135 °C / Inert atmosphere

2.1: dmap / dichloromethane / 0 - 20 °C

2.2: 0.05 h / 0 °C

With dmap; ammonia; In methanol; dichloromethane;
DOI:10.1021/ml300330m