2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

Base Information

Chemical Name:2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS No.:1420468-83-2
Molecular Formula:C₂₀H₂₂F₃N₅O
Molecular Weight:405.423
Hs Code.:

Synonyms:2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

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Chemical Property of 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

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Technology Process of 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

There total 11 articles about 2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 110-91-8,99108-56-2
morpholine

: 5-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}pyrazolo[1,5-a]pyrimidin-7-amine

: 1420468-83-2
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: In ethanol; at 140 ℃; for 7h; Microwave irradiation;

Reference yield: 24.0%

: 1420468-78-5
7-chloro-2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidine

: 1420468-83-2
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: With ammonia; In methanol; at 0 - 135 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml300330m

Reference yield:

: 1420468-30-9
2-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-3-oxobutanenitrile

: 1420468-83-2
2-methyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)pyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 7 steps

1: hydrazine hydrate / ethanol / 20 - 100 °C / Inert atmosphere

2: sodium methylate / methanol / 20 - 80 °C / Inert atmosphere

3: N,N-diethylaniline; trichlorophosphate / 3.25 h / 0 - 80 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran / 3 h / 50 °C

5: ethanol / 3 h / 145 °C / Microwave irradiation

6: N,N-diethylaniline; trichlorophosphate / 0.58 h / 0 - 80 °C / Inert atmosphere

7: ammonia / methanol / 3 h / 0 - 135 °C / Inert atmosphere

With ammonia; sodium methylate; hydrazine hydrate; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/ml300330m