[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:923563-43-3
Molecular Formula:C₁₆H₂₂ClFN₂O₄
Molecular Weight:360.813
Hs Code.:

Synonyms:[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of [2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

There total 1 articles about [2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 265983-08-2
2-(benzhydrylidene-amino)-N-methoxy-N-methyl-acetamide

: 24424-99-5
di-tert-butyl dicarbonate

: 923563-43-3
[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: 2-(benzhydrylidene-amino)-N-methoxy-N-methyl-acetamide; 5-chloro-2-fluorobenzyl bromide; With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; for 1 - 2h;

With hydrogenchloride; In diethyl ether; water; for 2h;

di-tert-butyl dicarbonate; With sodium hydroxide; more than 3 stages;

Reference yield:

: 923563-43-3
[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 923563-76-2
[3-(3-tert-butylcarbamoyl-pyridin-2-yl)-1-(5-chloro-2-fluoro-benzyl)-2-oxo-propyl]-carbamic acid tert-butyl ester

Guidance literature:: N-tert-butyl-2-methylnicotinamide; With sec.-butyllithium; In tetrahydrofuran; at -78 - -60 ℃; for 1 - 3h;

[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester; In tetrahydrofuran; at -78 ℃; for 0.5 - 2h;

In tetrahydrofuran; at -78 - 20 ℃; pH=< 7; Acidic conditions;

Reference yield:

: 923563-43-3
[2-(5-chloro-2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 2-[(2S,3R)-3-amino-4-(5-chloro-2-fluoro-phenyl)-2-hydroxy-butyl]-N-tert-butyl-nicotinamide dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sec.-butyllithium / tetrahydrofuran / 1 - 3 h / -78 - -60 °C

1.2: 0.5 - 2 h / -78 °C

1.3: -78 - 20 °C / pH < 7 / Acidic conditions

2.1: sodium tetrahydroborate / ethanol / 1 - 16 h / 0 - 20 °C

3.1: N,N-dimethyl-ethanamine; n-heptane; isopropyl alcohol / Resolution of racemate

4.1: trifluoroacetic acid / dichloromethane / 1 - 20 h

With sodium tetrahydroborate; sec.-butyllithium; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-ethanamine; ethanol; n-heptane; dichloromethane; isopropyl alcohol;