2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester

Base Information

• Chemical Name: 2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester
• CAS No.: 859856-02-3
• Molecular Formula: C₃₅H₄₄N₄O₁₂
• Molecular Weight: 712.754

Synonyms:2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester

Chemical Property of 2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester

Chemical Property:

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Technology Process of 2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester

There total 1 articles about 2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

bis(2-iodoethyl)cyanamide (877208-29-2) + diethyl 2-benzyloxycarbonylaminomalonate (3005-66-1) → 2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester (859856-02-3)

Guidance literature:

diethyl 2-benzyloxycarbonylaminomalonate; With sodium hydride; In N,N-dimethyl-formamide; at 5 - 12 ℃;

bis(2-iodoethyl)cyanamide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200702036

Reference yield: 98.0%

2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester (859856-02-3) → N,N-bis[(3-benzyloxycarbonylamino-3,3-diethoxycarbonyl)propyl]urea (1054553-28-4)

Guidance literature:

With sulfuric acid; water; In acetonitrile; at 80 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/chem.200702036

Reference yield:

2-benzyloxycarbonylamino-2-{2-[(3-benzyloxycarbonylamino-3,3-bis-ethoxycarbonyl-propyl)-cyano-amino]-ethyl}-malonic acid diethyl ester (859856-02-3) + ethanol (64-17-5) → C37H50N4O13*H(1+) (1054553-21-7)

Guidance literature:

With hydrogenchloride; at 45 ℃; Inert atmosphere;

DOI:10.1002/chem.200702036

upstream raw materials:

bis(2-iodoethyl)cyanamide

diethyl 2-benzyloxycarbonylaminomalonate

Downstream raw materials:

N,N-bis[(3-benzyloxycarbonylamino-3,3-diethoxycarbonyl)propyl]urea

C₃₇H₅₀N₄O₁₃*H⁽¹⁺⁾

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