2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Base Information

Chemical Name:2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide
CAS No.:1425927-06-5
Molecular Formula:C₂₀H₂₂N₂O₅S
Molecular Weight:402.471
Hs Code.:

Synonyms:2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

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Chemical Property of 2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

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Technology Process of 2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

There total 8 articles about 2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425927-05-4
methyl (2-{[(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)amino]sulfonyl}phenoxy)acetate

: 917-54-4
methyllithium

: 1425927-06-5
2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Guidance literature:: methyl (2-{[(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)amino]sulfonyl}phenoxy)acetate; methyllithium; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1425927-69-0
3-methyl-6-nitro-1H-quinolin-2-one

: 1425927-06-5
2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon; acetic acid / 3 h / 2585.81 Torr

2: pyridine / 96 h / 20 °C

3: tetrahydrofuran; diethyl ether / 1 h / 0 °C

With pyridine; palladium 10% on activated carbon; hydrogen; acetic acid; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1121-24-0
ortho-mercaptophenol

: 1425927-06-5
2-(2-hydroxy-2-methylpropoxy)-N-(3-methyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: potassium carbonate / acetonitrile / 16 h / Reflux

3: trichloroisocyanuric acid; acetic acid / acetonitrile; water / 16 h / 20 °C

4: pyridine / 96 h / 20 °C

5: tetrahydrofuran; diethyl ether / 1 h / 0 °C

With pyridine; trichloroisocyanuric acid; potassium carbonate; potassium hydrogencarbonate; acetic acid; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;