2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole
CAS No.:1571031-84-9
Molecular Formula:C₂₁H₁₄ClF₃N₄O₃
Molecular Weight:462.815
Hs Code.:

Synonyms:2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

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Chemical Property of 2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

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Technology Process of 2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

There total 4 articles about 2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 101990-73-2
2-chloro-pyridin-4-ylmethyl chloride

: 1571031-76-9
6-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one

: 1571031-84-9
2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

: 1571031-80-5
1-((2-chloropyridin-4-yl)methyl)-6-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 65 ℃; for 16h;

Reference yield:

: 38116-61-9
6-Methylpyrid-2-one-3-carboxylic Acid

: 1571031-84-9
2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

2: Burgess Reagent / tetrahydrofuran / 1 h / 60 °C / Microwave irradiation

3: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 65 °C

With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; Burgess Reagent; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 175277-18-6
4-trifluoromethoxybenzoyl hydrazine

: 1571031-84-9
2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

2: Burgess Reagent / tetrahydrofuran / 1 h / 60 °C / Microwave irradiation

3: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 65 °C

With 2-(1H-9-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate; Burgess Reagent; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;