tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1383823-81-1
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 4 articles about tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383823-79-7
4-(bromomethyl)-5-cyclopropyl-3-(o-tolyl)isoxazole

: 143557-91-9
(1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1383823-81-1
tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: With 18-crown-6 ether; potassium tert-butylate; In tetrahydrofuran; for 2h; Inert atmosphere;

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 1383823-81-1
tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / 0 - 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3.1: sodium methylate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

4.2: 0.5 h / 20 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

6.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 2 h / Inert atmosphere

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2-methyl-N-hydroxybenzenecarboximidoyl chloride

: 1383823-81-1
tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

4.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 2 h / Inert atmosphere

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;