5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

Base Information

Chemical Name:5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid
CAS No.:1185582-94-8
Molecular Formula:C₂₁H₂₂F₃NO₅
Molecular Weight:425.405
Hs Code.:

Synonyms:5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

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Chemical Property of 5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

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Technology Process of 5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

There total 6 articles about 5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 927685-43-6
2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 1185582-94-8
5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

Guidance literature:: 2-hydroxy-5-[2-(4-(trifluoromethylphenyl)ethylamino)]benzoic acid; di-tert-butyl dicarbonate; With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; water; pH=6;

Reference yield:

: 89-57-6
5-Aminosalicylic Acid

: 1185582-94-8
5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C

2.2: pH 6

With sodium carbonate; triethylamine; tetra-(n-butyl)ammonium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1042742-27-7
methyl 2-acetoxy-5-(2-(4-trifluoromethyl-phenyl)acetamido)benzoate

: 1185582-94-8
5-(tert-butoxycarbonyl-(4-(trifluoromethyl)phenylethyl)amino)-2-hydroxy benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / 1,4-dioxane; acetic acid / 0.83 h / 95 °C

2.1: hydrogenchloride; water

3.1: sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C

3.2: pH 6

With hydrogenchloride; sodium tetrahydroborate; water; sodium carbonate; In 1,4-dioxane; water; acetic acid;