2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

Base Information

Chemical Name:2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid
CAS No.:1028312-81-3
Molecular Formula:C₃₈H₅₂O₅SSi
Molecular Weight:648.979
Hs Code.:

2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

Synonyms:2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

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Chemical Property of 2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

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Technology Process of 2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

There total 5 articles about 2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 249588-51-0
2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid diallyl ester

: 1028312-81-3
2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1055/s-1999-2858

Reference yield:

: 3695-77-0
triphenylmethanethiol

: 1028312-81-3
2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 63 percent / KF / methanol / 36 h / 20 °C

2.1: 88 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

3.1: NaH / dimethylformamide / 1 h / 20 °C

3.2: 53 percent / TBAI; imidazole / dimethylformamide / 18 h / 80 °C

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 91 percent / KI / dimethylformamide / 12 h / 50 °C

5.1: morpholine / (Ph₃P)4Pd / tetrahydrofuran / 3 h / 20 °C

With morpholine; 1H-imidazole; dmap; potassium fluoride; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Substitution / 3.1: Metallation / 3.2: Alkylation / 4.1: Metallation / 4.2: Alkylation / 5.1: Substitution;
DOI:10.1055/s-1999-2858

Reference yield:

: 249588-46-3
Toluene-4-sulfonic acid (S)-2-hydroxy-3-tritylsulfanyl-propyl ester

: 1028312-81-3
2-[2-(tert-butyl-dimethyl-silanyloxy)-3-tritylsulfanyl-propyl]-2-heptyl-malonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / imidazole; DMAP / CH₂Cl₂ / 12 h / 20 °C

2.1: NaH / dimethylformamide / 1 h / 20 °C

2.2: 53 percent / TBAI; imidazole / dimethylformamide / 18 h / 80 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 91 percent / KI / dimethylformamide / 12 h / 50 °C

4.1: morpholine / (Ph₃P)4Pd / tetrahydrofuran / 3 h / 20 °C

With morpholine; 1H-imidazole; dmap; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Substitution / 2.1: Metallation / 2.2: Alkylation / 3.1: Metallation / 3.2: Alkylation / 4.1: Substitution;
DOI:10.1055/s-1999-2858