(1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

Base Information

Chemical Name:(1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol
CAS No.:139118-54-0
Molecular Formula:C₁₆H₃₂O₂Si
Molecular Weight:284.514
Hs Code.:

Synonyms:(1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

Chemical Property:

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Technology Process of (1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

There total 4 articles about (1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123427-43-0
(3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanone

: 139118-54-0
(1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 - 5 ℃; for 2h;

Reference yield:

: 106540-31-2
(+)-(S)-3-(tert-butyldimethylsiloxy)-2,2-dimethylcyclohexanone

: 139118-54-0
(1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1) lithium diisopropylamide / 1) THF/hexane, -78 degC, 30 min, 2) THF, -78 degC, 1 h

2: 88 percent / NaBH₄ / tetrahydrofuran; ethanol / 2 h / 0 - 5 °C

With sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; ethanol;

Reference yield:

: 139118-53-9
(3S)-3-(t-Butyldimethylsiloxy)-6-(1-hydroxyethyl)-2,2-dimethylcyclohexanone

: 139118-54-0
(1R,3S)-3-(t-Butyldimethylsiloxy)-6-ethylidene-2,2-dimethylcyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 1a) 0 to 5 degC, 2 h, 1b) r.t., 1 h

2: 56.0 g / DBU / tetrahydrofuran / 1 h / 50 °C

3: 88 percent / NaBH₄ / tetrahydrofuran; ethanol / 2 h / 0 - 5 °C

With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; ethanol;