(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

Base Information

Chemical Name:(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine
CAS No.:1355159-10-2
Molecular Formula:C₂₄H₂₀F₃N₃O
Molecular Weight:423.438
Hs Code.:

Synonyms:(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

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Chemical Property of (1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

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Technology Process of (1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

There total 7 articles about (1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1355159-11-3
tert-butyl [(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethyl]carbamate

: 1355159-10-2
(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

Guidance literature:: With hydrogenchloride; acetic acid; at 20 ℃; for 1h;

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1355159-10-2
(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 3.08 h / Inert atmosphere; Reflux

2.1: sodium hydroxide / ethanol / 2 h / 20 - 60 °C

2.2: pH 2

3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 5 - 9 °C / Inert atmosphere; Cooling with ice

3.2: 2.5 h

4.1: toluene / 100 °C

5.1: hydrogenchloride; acetic acid / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; acetic acid; sodium hydroxide; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

: 161622-14-6
4-bromo-3-(trifluoromethyl)benzoic acid

: 1355159-10-2
(1R)-1-(4-{5-[2'-methyl-2-(trifluoromethyl)biphenyl-4-yl]-1,2,4-oxadiazol-3-yl}phenyl)ethanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 12 h / 20 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 3.08 h / Inert atmosphere; Reflux

3.1: sodium hydroxide / ethanol / 2 h / 20 - 60 °C

3.2: pH 2

4.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / 5 - 9 °C / Inert atmosphere; Cooling with ice

4.2: 2.5 h

5.1: toluene / 100 °C

6.1: hydrogenchloride; acetic acid / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; potassium carbonate; acetic acid; sodium hydroxide; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; toluene;