(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Base Information

Chemical Name:(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate
CAS No.:948842-89-5
Molecular Formula:C₃₅H₃₉N₇O₈
Molecular Weight:685.737
Hs Code.:

(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Synonyms:(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

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Chemical Property of (S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

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Technology Process of (S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

There total 10 articles about (S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 623155-48-6
4-chloro-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide

: 948842-88-4
(S)-((3-amino-4-methylbenzoyl)(cyclopropyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

: 948842-89-5
(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

: 948842-72-6
chloromethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

: 948842-89-5
(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / acetone / Reflux

2: toluene / Reflux

3: zinc; ammonium chloride / tetrahydrofuran; methanol / 20 °C

4: N,N-dimethyl-formamide / 20 °C

With ammonium chloride; sodium iodide; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

: 303133-89-3
N-cyclopropyl-4-methyl-3-nitrobenzamide

: 948842-89-5
(S)-(cyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]-triazin-4-ylamino)benzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 0 - 20 °C

2.1: sodium iodide / acetone / Reflux

3.1: toluene / Reflux

4.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 20 °C

5.1: N,N-dimethyl-formamide / 20 °C

With ammonium chloride; sodium iodide; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.022