iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

Base Information

• Chemical Name: iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate
• CAS No.: 948842-74-8
• Molecular Formula: C₁₃H₁₃IN₂O₅
• Molecular Weight: 404.161
• Mol file: 948842-74-8.mol

Synonyms:iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

Chemical Property of iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

There total 2 articles about iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

chloromethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-72-6) → iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-74-8)

Guidance literature:

With sodium iodide; In acetone; for 1.25h; Heating / reflux;

Reference yield:

N-cyclopropyl-4-methyl-3-nitrobenzamide (303133-89-3) → iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 0 - 20 °C

2.1: sodium iodide / acetone / Reflux

With sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; acetone;

DOI:10.1016/j.bmcl.2013.03.022

Reference yield: 83.0%

silver dibenzylphosphate (50651-75-7) + iodomethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-74-8) → (bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-nitrobenzoyl)carbamate (948842-76-0)

Guidance literature:

In toluene; for 1.25h; Heating / reflux;

upstream raw materials:

chloromethyl cyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

N-cyclopropyl-4-methyl-3-nitrobenzamide

Downstream raw materials:

(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-nitrobenzoyl)carbamate

(S)-(cyclopropyl(4-methyl-3-nitrobenzoyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

(bis(benzyloxy)phosphoryloxy)methyl-3-amino-4-methylbenzoyl(cyclopropyl)-carbamate

(bis(benzyloxy)phosphoryloxy)methylcyclopropyl(4-methyl-3-(5-methyl-6-(propylcarbamoyl)pyrrolo[1,2-f][1,2,4]triazin-4-ylamino)benzoyl)carbamate