(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

Base Information

Chemical Name:(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester
CAS No.:1400660-93-6
Molecular Formula:C₂₅H₂₆ClN₃O₆S₂
Molecular Weight:564.083
Hs Code.:

Synonyms:(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

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Chemical Property of (S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

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Technology Process of (S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

There total 12 articles about (S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 513-38-2
Isobutyl iodide

: 1400660-92-5
(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid

: 1400660-93-6
(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 873-62-1
m-cyanophenol

: 1400660-93-6
(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 2585.81 Torr

3: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 15 h / 20 °C

4: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h

5: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

6: dichloromethane / 1 h / 20 °C

7: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / N,N-dimethyl-formamide / 15 h / 20 °C

8: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h / 20 °C

9: triethylamine / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

With 1H-imidazole; lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 160833-27-2
3-(tert-butyldimethylsilyloxy)benzonitrile

: 1400660-93-6
(S)-2-{[3-Chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-3-[(thiophene-2-carbonyl)-amino]-propionic acid isobutyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 2585.81 Torr

2: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 15 h / 20 °C

3: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h

4: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

5: dichloromethane / 1 h / 20 °C

6: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / N,N-dimethyl-formamide / 15 h / 20 °C

7: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h / 20 °C

8: triethylamine / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

With lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;