tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Base Information

Chemical Name:tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate
CAS No.:192944-46-0
Molecular Formula:C₄₉H₅₃N₇O₅S
Molecular Weight:852.07
Hs Code.:

tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Synonyms:tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

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Chemical Property of tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

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Technology Process of tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

There total 7 articles about tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 185563-98-8
3S-3-amino-2-(2,4,6-trimethylbenzenesulfonylamino)propionic acid tert-butyl ester

: 192944-55-1
1-[3-(N-(1-triphenylmethylimidazol-2-yl)amino)propyl]indazole-5-carboxylic acid

: 192944-46-0
tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jm990049j

Reference yield: 75.0%

: 192944-46-0
tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Guidance literature:

Reference yield:

: 192944-51-7
1H-indazole-5-carboxylic acid ethyl ester

: 192944-46-0
tert-Butyl 3-[1-[3-(N-(1-triphenylmethylimidazol-2-yl)-amino)propyl]-indazol-5-ylcarbonylamino]-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / NaN(TMS)2; 18-crown-6 / tetrahydrofuran / 20 h / Heating

2: 98 percent / aq. HOAc / 20 h / 70 °C

3: toluene / 20 h / Heating

4: NaBH(OAc)3 / toluene / 20 h

5: 85 percent / 1.0 M aq. NaOH / ethanol / 4 h / Heating

6: 75 percent / DCC; HOBT / dimethylformamide / 24 h

With sodium hydroxide; 18-crown-6 ether; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: acidolysis / 3: Condensation / 4: Reduction / 5: Hydrolysis / 6: Condensation;
DOI:10.1021/jm990049j