185563-98-8Relevant articles and documents
Design and synthesis of a new class of selective integrin α5β1 antagonists
Stragies, Roland,Osterkamp, Frank,Zischinsky, Gunther,Vossmeyer, Doerte,Kalkhof, Holger,Reimer, Ulf,Zahn, Grit
, p. 3786 - 3794 (2008/02/11)
Starting from the structure of integrin αvβ3 in a complex with a peptidic ligand plus SAR data on nonpeptidic ligands, we derived a new class of integrin α5β1 antagonists (1). Several synthesis strategies were applied to evaluate the chemical space around
1,3,4-thiadiazoles and 1,3,4-Oxadiazoles as alpha v beta 3 antagonists
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, (2008/06/13)
This invention relates to 1,3,4-thiadiazoles and 1,3,4-Oxadiazoles of Formula (I) which are useful as antagonists of alpha v beta 3 and related integrin receptors, to pharmaceutical compositions containing such compounds, alone or in combination with othe
Integrin receptor antagonists
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, (2008/06/13)
This invention relates to novel heterocycles including 3-?1-?3-(imidazolin-2-ylamino)propyl!indazol-5-ylcarbonylamino!-2-(benzyloxycarbonylamino)propionic acid, which are useful as antagonists of the αv β3 integrin and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.