3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate

Base Information

Chemical Name:3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate
CAS No.:1448317-57-4
Molecular Formula:C₂HF₃O₂*C₁₆H₂₃NO₂
Molecular Weight:375.388
Hs Code.:

Synonyms:3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate

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Chemical Property of 3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate

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Technology Process of 3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate

There total 2 articles about 3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 123-75-1
pyrrolidine

: 1289124-26-0
3-tert-butyl-5-formylbenzoic acid

: 76-05-1
trifluoroacetic acid

: 1448317-57-4
3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate

Guidance literature:: pyrrolidine; 3-tert-butyl-5-formylbenzoic acid; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; water; at 20 ℃; for 2h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1041053-70-6
methyl 3-tert-butyl-5-formylbenzoate

: 1448317-57-4
3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / 1 h / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; water / 2 h / 20 °C

With lithium hydroxide monohydrate; water; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; water;