(E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester
CAS No.:326606-18-2
Molecular Formula:C₃₆H₄₅NO₁₂
Molecular Weight:683.753
Hs Code.:

Synonyms:(E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

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Chemical Property of (E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

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Technology Process of (E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

There total 6 articles about (E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 326606-17-1
(3S,5S,6S)-3-[(1S,3R)-1-methoxy-3-methyl-4-(5-nitro-2,3,6-trimethoxy-phenyl)-butyl]-5,6-bis-(4-methoxy-phenyl)-[1,4]dioxan-2-ol

: 326606-18-2
(E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

: (2Z,4R,5S,7R)-4-[(1S,2S)-2-hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(5-nitro-2,3,6-trimethoxy-phenyl)-oct-2-enoic acid methyl ester

Guidance literature:: With lithium chloride; In acetonitrile;
DOI:10.1021/jo034870l

Reference yield:

: 4705-34-4,15638-14-9,34480-01-8,112246-67-0,2510-75-0
1,2-bis(4-methoxyphenyl)ethene

: 326606-18-2
(E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / AD-mix-α; H2O / 2-methyl-propan-2-ol

2.1: n-Bu₂SnO / benzene / Heating

2.2: 76 percent / tetra-n-butylammonium iodide / benzene

3.1: Et₃N; cHex₂BOTf / CH₂Cl₂; hexane / 3 h / -78 °C

3.2: 70 percent / CH₂Cl₂; hexane / 3 h / -78 °C

4.1: 91 percent / proton sponge / CH₂Cl₂ / 8 h / 20 °C

5.1: 91 percent / DIBAL-H

6.1: 93 percent / LiCl / acetonitrile

With AD-mix-α; Proton Sponge; water; diisobutylaluminium hydride; di(n-butyl)tin oxide; triethylamine; lithium chloride; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jo034870l

Reference yield:

: 122798-27-0
(-)-(2S,3S)-1,2-bis(4-methoxyphenyl)ethane1,2-diol

: 326606-18-2
(E)-(4R,5S,7R)-4-[(1S,2S)-2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-ethoxy]-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-Bu₂SnO / benzene / Heating

1.2: 76 percent / tetra-n-butylammonium iodide / benzene

2.1: Et₃N; cHex₂BOTf / CH₂Cl₂; hexane / 3 h / -78 °C

2.2: 70 percent / CH₂Cl₂; hexane / 3 h / -78 °C

3.1: 91 percent / proton sponge / CH₂Cl₂ / 8 h / 20 °C

4.1: 91 percent / DIBAL-H

5.1: 93 percent / LiCl / acetonitrile

With Proton Sponge; diisobutylaluminium hydride; di(n-butyl)tin oxide; triethylamine; lithium chloride; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1021/jo034870l