(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

Base Information

• Chemical Name: (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate
• CAS No.: 873551-03-2
• Molecular Formula: C₄H₆O₆*C₂₂H₃₁NO
• Molecular Weight: 475.582
• Mol file: 873551-03-2.mol

Synonyms:(S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

Chemical Property of (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate

There total 10 articles about (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate (873551-03-2,209747-05-7)

Guidance literature:

Reference yield: 45.0%

racemic tolterodine hydrogen sulfate (944241-58-1) + L-Tartaric acid (87-69-4,138508-61-9) → (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate (873551-03-2,209747-05-7)

Guidance literature:

racemic tolterodine hydrogen sulfate; With methylamine; In water; toluene;

L-Tartaric acid; In ethanol; water; toluene; at 80 ℃; Resolution of racemate; (+)-tolterodine tartrate;

Reference yield: 40.0%

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine hydrochloride → (S)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate (873551-03-2,209747-05-7)

Guidance literature:

In methanol; acetonitrile;

DOI:10.1021/op050024w

upstream raw materials:

L-Tartaric acid

N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine

racemic tolterodine hydrogen sulfate

(+/-)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propanamide

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF N,N-DIISOPROPYL-3-(2-HYDROXY-5-METHYLPHENYL)- 3-PHENYL PROPYLAMINE AND ITS SALTS STARTING FROM A NOVEL INTERMEDIATE". Page/Page column 24. . Retrieved 2012/08/07.
• 2、 -. "ENANTIOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY ENRICHED COMPOUNDS". Page/Page column 13. . Retrieved 2010/02/10.