Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, cis- (9CI)

Base Information

• Chemical Name: Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, cis- (9CI)
• CAS No.: 105919-35-5
• Molecular Formula: C₈H₁₄FNO₂
• Molecular Weight: 175.203
• Mol file: 105919-35-5.mol

Synonyms:Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, cis- (9CI)

Chemical Property of Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, cis- (9CI)

Chemical Property:

• PSA: 38.33000
• LogP: 2.01240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, cis- (9CI)

There total 5 articles about Carbamic acid, (2-fluorocyclopropyl)-, 1,1-dimethylethyl ester, cis- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R*,2S*)-2-fluorocyclopropylamine hydrochloride (114152-95-3,114152-96-4,141042-20-8,141042-21-9,143062-71-9,143062-74-2,143062-85-5) → tert-butyl dl-N-(cis-2-fluorocyclopropyl)carbamate (105919-35-5,127199-15-9,127199-16-0,142977-47-7,143022-91-7,143840-33-9,146726-40-1,167073-09-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(01)89665-4

Reference yield: 28.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R*,2R*)-2-fluorocyclopropylamine hydrochloride (114152-95-3,114152-96-4,141042-20-8,141042-21-9,143062-71-9,143062-74-2,143062-85-5) → tert-butyl dl-N-(trans-2-fluorocyclopropyl)carbamate (105919-35-5,127199-15-9,127199-16-0,142977-47-7,143022-91-7,143840-33-9,146726-40-1,167073-09-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4020(01)89665-4

Reference yield: 18.0%

fluorodiiodomethane (1493-01-2) + t-butyl N-vinylcarbamate (7150-72-3) → tert-butyl dl-N-(trans-2-fluorocyclopropyl)carbamate (105919-35-5,127199-15-9,127199-16-0,142977-47-7,143022-91-7,143840-33-9,146726-40-1,167073-09-8) + tert-butyl dl-N-(cis-2-fluorocyclopropyl)carbamate (105919-35-5,127199-15-9,127199-16-0,142977-47-7,143022-91-7,143840-33-9,146726-40-1,167073-09-8)

Guidance literature:

With 1,2-dimethoxyethane; 4 A molecular sieve; diethylzinc; In hexane; dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)89665-4

upstream raw materials:

fluorodiiodomethane

t-butyl N-vinylcarbamate

di-tert-butyl dicarbonate

(1R*,2R*)-2-fluorocyclopropylamine hydrochloride

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