[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

Base Information

Chemical Name:[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid
CAS No.:221302-05-2
Molecular Formula:C₃₂H₃₂N₂O₈
Molecular Weight:572.615
Hs Code.:

Synonyms:[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

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Chemical Property of [(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

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Technology Process of [(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

There total 5 articles about [(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 221302-03-0
[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

: 221302-05-2
[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 4h;
DOI:10.1039/a808505f

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 221302-05-2
[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / CH₂Cl₂ / 1 h

2: 67 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / Bu₃SnH, AIBN / toluene / 8 h / 65 °C

4: 67 percent / H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1039/a808505f

Reference yield:

: 185141-87-1
[(2R,3R,4S,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

: 221302-05-2
[(2R,3S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / CH₂Cl₂ / 1 h

2: 67 percent / Et₃N, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

3: 88 percent / Bu₃SnH, AIBN / toluene / 8 h / 65 °C

4: 67 percent / H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 4 h

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1039/a808505f