[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Base Information

Chemical Name:[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester
CAS No.:185141-90-6
Molecular Formula:C₄₅H₄₂N₂O₉
Molecular Weight:754.836
Hs Code.:

[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Synonyms:[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

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Chemical Property of [(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

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Technology Process of [(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

There total 10 articles about [(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 185141-87-1
2'-deoxy-2'-α-C-(O-diphenylmethyl carboxymethyl)uridine

: 185141-90-6
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Guidance literature:: With pyridine; In dichloromethane; for 1h;
DOI:10.1021/jo9614607

Reference yield: 82.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 185141-87-1
[(2R,3R,4S,5R)-2-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

: 185141-90-6
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Guidance literature:: With pyridine; In dichloromethane; for 1h;
DOI:10.1039/a808505f

Reference yield:

: 1-((2R,3R,3aS,9aR)-3-Allyl-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-hydroxy-1H-pyrimidin-2-one

: 185141-90-6
[(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-2-(4-hydroxy-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-acetic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 99.6 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 1.5 h

2: NaIO₄ / dioxane; H₂O / 0.17 h

3: 94 percent / 2-methyl-2-butene, NaClo₂, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 1 h

4: 75 percent / acetone / 4 h

5: 87 percent / Et₃N*HF / tetrahydrofuran

6: 86 percent / pyridine / CH₂Cl₂ / 1 h

With pyridine; sodium chlorite; sodium periodate; potassium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; triethylamine hydrofluoride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jo9614607