2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

Base Information

Chemical Name:2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide
CAS No.:227467-58-5
Molecular Formula:C₁₅H₁₇ClF₃NO₃
Molecular Weight:351.753
Hs Code.:

Synonyms:2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

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Chemical Property of 2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

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Technology Process of 2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

There total 3 articles about 2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 227467-57-4
2'-chloro-4'-(2-hydroxyethyl)-2,2,2-trifluoroacetanilide

: 227467-58-5
2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 1h; Heating;
DOI:10.1021/jm000455z

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 227467-57-4
2'-chloro-4'-(2-hydroxyethyl)-2,2,2-trifluoroacetanilide

: 227467-58-5
2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; for 1h; Heating / reflux;

Reference yield:

: 26407-02-3
4-amino-3-chlorophenethyl alcohol

: 227467-58-5
2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N / tetrahydrofuran / 0.17 h

2: 78 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 1 h / Heating

With pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm000455z