ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate

Base Information

• Chemical Name: ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate
• CAS No.: 344285-89-8
• Molecular Formula: C₁₉H₂₃ClF₃NO₅
• Molecular Weight: 437.844

Synonyms:ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate

Chemical Property of ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate

Chemical Property:

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Technology Process of ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate

There total 5 articles about ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethyl bromoacetate (105-36-2) + 2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide (227467-58-5) → ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate (344285-89-8)

Guidance literature:

2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Further stages.;

DOI:10.1021/jm000455z

Reference yield:

2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide (227467-58-5) + ethyl bromoacetate (105-36-2) → ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate (344285-89-8)

Guidance literature:

2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

ethyl bromoacetate; In DMF (N,N-dimethyl-formamide); for 16h;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → ethyl N-[2-chloro-4-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]phenyl]-N-trifluoroacetylaminoacetate (344285-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 1 h / Heating

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 57 percent / dimethylformamide / 16 h / 20 °C

With pyridinium p-toluenesulfonate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000455z

upstream raw materials:

ethyl bromoacetate

2'-chloro-4'-[2-((RS)-tetrahydropyran-2-yloxy)ethyl]-2,2,2-trifluoroacetanilide

3,4-dihydro-2H-pyran

4-amino-3-chlorophenethyl alcohol

Downstream raw materials:

ethyl N-[4-(2-bromoethyl)-2-chlorophenyl]-N-methylaminoacetate

ethyl N-[4-(2-bromoethyl)-2-chlorophenyl]aminoacetate

ethyl N-[2-chloro-4-(2-hydroxyethyl)phenyl]aminoacetate

ethyl N-[2-chloro-4-(2-hydroxyethyl)phenyl]-N-methylaminoacetate

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