Technology Process of C47H58N2O10SSi
There total 8 articles about C47H58N2O10SSi which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,2-dimethoxyethane;
at -78 ℃;
C18H25NO6S;
In
tetrahydrofuran; 1,2-dimethoxyethane;
at -78 ℃;
DOI:10.1021/jo9817117
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Ph3P; DEAD / tetrahydrofuran
2.1: n-BuLi / diethyl ether
3.1: H2 / Pd/CaCO3/Pb / toluene
4.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C
4.2: 71 percent / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C
With
n-butyllithium; hydrogen; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
Lindlar's catalyst;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; toluene;
1.1: Alkylation / 2.1: Acylation / 3.1: Catalytic hydrogenation / 4.1: Metallation / 4.2: Michael addition;
DOI:10.1021/jo9817117
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 54 percent / BH3*Me2S; NaBH4 / tetrahydrofuran
2.1: 82 percent / imidazole / tetrahydrofuran
3.1: H2 / Pd/C / ethyl acetate
4.1: CH2Cl2
5.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C
5.2: 71 percent / tetrahydrofuran; 1,2-dimethoxy-ethane / -78 °C
With
1H-imidazole; sodium tetrahydroborate; dimethylsulfide borane complex; hydrogen; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
1.1: Reduction / 2.1: silylation / 3.1: Catalytic hydrogenation / 4.1: Cyclization / 5.1: Metallation / 5.2: Michael addition;
DOI:10.1021/jo9817117
