1-Benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine

Base Information

Chemical Name:1-Benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine
CAS No.:127625-95-0
Molecular Formula:C₂₀H₂₃NO₃
Molecular Weight:325.408
Hs Code.:
DSSTox Substance ID:DTXSID901200038

Synonyms:127625-95-0;1-benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine;1-Piperidinecarboxylic acid, 4-(4-methoxyphenyl)-, phenylmethyl ester;SCHEMBL8316392;QDMZVZQDMUTIHI-UHFFFAOYSA-N;DTXSID901200038;benzyl 4-(4-methoxyphenyl)piperidine-1-carboxylate;Phenylmethyl 4-(4-methoxyphenyl)-1-piperidinecarboxylate

Suppliers and Price of 1-Benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-Benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:325.16779360
Heavy Atom Count:24
Complexity:378

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2CCN(CC2)C(=O)OCC3=CC=CC=C3

Technology Process of 1-Benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine

There total 5 articles about 1-Benzyloxycarbonyl-4-(4-methoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: C₂₀H₂₁N₅O₄S

: 127625-95-0
benzyl 4-(4-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: With pyridine-2,6-bis(carboximidamide) dihydrochloride; nickel dibromide; zinc; at 100 ℃; for 24h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.orglett.9b01987

Reference yield:

: 166953-64-6
benzyl 4-bromo-1-piperidinecarboxylate

: 127625-95-0
benzyl 4-(4-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 48 h / 70 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / 0 - 22 °C / Inert atmosphere

3: nickel dibromide; pyridine-2,6-bis(carboximidamide) dihydrochloride; zinc / 24 h / 100 °C / Inert atmosphere; Sealed tube

With pyridine-2,6-bis(carboximidamide) dihydrochloride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; nickel dibromide; zinc; In dichloromethane; acetone;
DOI:10.1021/acs.orglett.9b01987

Reference yield:

: C₂₀H₂₁N₅O₂S

: 127625-95-0
benzyl 4-(4-methoxyphenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / 0 - 22 °C / Inert atmosphere

2: nickel dibromide; pyridine-2,6-bis(carboximidamide) dihydrochloride; zinc / 24 h / 100 °C / Inert atmosphere; Sealed tube

With pyridine-2,6-bis(carboximidamide) dihydrochloride; 3-chloro-benzenecarboperoxoic acid; nickel dibromide; zinc; In dichloromethane;
DOI:10.1021/acs.orglett.9b01987