166953-64-6

Basic information

• Product Name: BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• Synonyms: N-CBZ-4-BROMO-PIPERIDINE;4-BROMO-N-Z-PIPERIDINE;BUTTPARK 93\50-52;BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;4-Bromopiperidine, N-CBZ protected;4-BROMO-N-Z-PIPERIDINE,96%;4-bromo-n-cbz piperidine;Benzyl 4-bromotetrahydro-1(2H)-pyridinecarboxylate, 90+%
• CAS NO: 166953-64-6
• Molecular Formula: C₁₃H₁₆BrNO₂
• Molecular Weight: 298.18
• Product Categories: API intermediates;C12 to C13;Building Blocks;C13;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Piperidines
• Mol File: 166953-64-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 144 °C
• Flash Point: >230 °F
• Appearance: /
• Density: 1.374 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.91E-06mmHg at 25°C
• Refractive Index: n20/D 1.5590(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.82±0.40(Predicted)
• CAS DataBase Reference: BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(166953-64-6)
• EPA Substance Registry System: BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE(166953-64-6)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• WGK Germany: 3
• Hazardous Substances Data: 166953-64-6(Hazardous Substances Data)

Usage

General Description

Benzyl 4-bromotetrahydro-1(2H)-pyridinecarboxylate is a chemical compound with the molecular formula C14H16BrNO2. It is a member of the pyridinecarboxylate class of compounds, which are often used as pharmaceutical intermediates. Benzyl 4-bromotetrahydro-1(2H)-pyridinecarboxylate is a white to off-white crystalline powder and is mainly used in the production of various pharmaceutical drugs. It has applications in the synthesis of active pharmaceutical ingredients (APIs) and is commonly used in the pharmaceutical industry. BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE possesses potential biological activity and is an important building block for the synthesis of many pharmaceuticals.

InChI:InChI=1/C13H16BrNO2/c14-12-6-8-15(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2

Upstream product

• 90633-18-4 4-bromo-1H-piperidine 
• 501-53-1 benzyl chloroformate 
• 54288-70-9 4-bromopiperidine hydrobromide 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 1972-28-7 diethylazodicarboxylate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 690257-75-1 benzyl 4-fluoropiperidine-1-carboxylate 
• 1380313-68-7 4-(2-4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl)piperidine-1-carboxylic acid benzyl ester 
• 66207-23-6 1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine 
• 3742-91-4 N-(benzyloxycarbonyl)piperidine 
• 733810-73-6 phenylmethyl 4-phenylhexahydropyridine-1-carboxylate 

Relevant articles and documents

Copper-Catalyzed Reductive Cross-Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides

A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl C=C bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo- or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.

1-(4-PIPERIDINYL) BENZIMIDAZOLONES AS HISTAMINE H3 ANTAGONISTS

Disclosed are histamine H3 antagonists of the formula (I) wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined