3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

Base Information

Chemical Name:3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester
CAS No.:143879-85-0
Molecular Formula:C₁₇H₂₁Cl₂FN₂O₃Si
Molecular Weight:419.355
Hs Code.:

Synonyms:3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

Suppliers and Price of 3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

There total 1 articles about 3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 143879-85-0
3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, hexane, -73 deg C, 3 h, 2.) THF, hexane, from -66 deg C, 1 h

2: 19.7 g / oxalyl dichloride, DMF / CH₂Cl₂ / 5 h / 25 °C

3: 1.) BuLi / 1.) THF, hexane, -25 deg C, 30 min, 2.) THF, hexane, -70 deg C, 1.5 h

4: 30.6 g / acetic anhydride / 120 °C

5: ethanol / 2 h / Ambient temperature

With n-butyllithium; oxalyl dichloride; acetic anhydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In ethanol; dichloromethane;
DOI:10.1002/jhet.5570290453

Reference yield:

: 143879-85-0
3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

: 7-(N-tert-butyloxycarbonylpiperazin-1-yl)-6-fluoro-5-formyl-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / NaH / dioxane / 1.5 h / 45 °C

2: 24 percent / POCl₃ / 1,2-dichloro-benzene / 2 h / 90 - 100 °C

3: 58 percent / acetonitrile / 2 h / 40 °C

With sodium hydride; trichlorophosphate; In 1,4-dioxane; 1,2-dichloro-benzene; acetonitrile;
DOI:10.1002/jhet.5570290453

Reference yield:

: 143879-85-0
3-(2,6-dichloro-4-trimethylsilyl-3-fluoro-5-pyridinyl)-3-oxo-2-<((cyclopropyl)amino)methylene>propanoic acid ethyl ester

: 7-(N-tert-butyloxycarbonylpiperazin-1-yl)-6-fluoro-5-hydroxymethyl-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / NaH / dioxane / 1.5 h / 45 °C

2: 24 percent / POCl₃ / 1,2-dichloro-benzene / 2 h / 90 - 100 °C

3: 58 percent / acetonitrile / 2 h / 40 °C

4: 30 percent / NaBH₄ / methanol / 1.5 h / 0 °C

With sodium tetrahydroborate; sodium hydride; trichlorophosphate; In 1,4-dioxane; methanol; 1,2-dichloro-benzene; acetonitrile;
DOI:10.1002/jhet.5570290453