N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Base Information

• Chemical Name: N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat
• CAS No.: 75074-03-2
• Molecular Formula: C₃₂H₃₈ClN₆O₈PSi
• Molecular Weight: 729.201
• Mol file: 75074-03-2.mol

Synonyms:N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Chemical Property of N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

There total 9 articles about N⁶-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-01-0) → N6-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-03-2)

Guidance literature:

With trifluoroacetic acid; In chloroform; for 0.5h; Ambient temperature;

Reference yield:

2-chlorophenyl dichlorophosphate (15074-54-1) → N6-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-03-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 86 percent / trifluoro acetic acid / CHCl₃ / 0.5 h / Ambient temperature

With trifluoroacetic acid; In chloroform;

Reference yield:

N6-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine (69504-10-5) → N6-Benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat (75074-03-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 86 percent / trifluoro acetic acid / CHCl₃ / 0.5 h / Ambient temperature

With trifluoroacetic acid; In chloroform;

upstream raw materials:

N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

N⁶-Benzoyl-3'-O-<(tert-butyl)dimethylsilyl>-5'-O-(monomethoxytrityl)adenosine

2-chlorophenyl dichlorophosphate

Phosphoric acid (2R,3R,4R,5R)-2-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-chloro-phenyl ester

Downstream raw materials:

N⁶-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenylyl<3'-P-(2-chlorphenyl)>-5'>-N⁶-benzoyl-3'-O-(tert-butyldimethylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat

N⁶-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-(4-methoxytrityl)adenylyl<2'-P-(2-chlorphenyl)>-5'->-N⁶-benzoyl-3'-O-(tert-butyldimetylsilyl)adenosin-2'-(2-chlorphenyl)(2-cyanethyl)phosphat