Benzenepropanoic acid, 4-hydroxy-2-methyl-, methyl ester

Base Information

• Chemical Name: Benzenepropanoic acid, 4-hydroxy-2-methyl-, methyl ester
• CAS No.: 105731-18-8
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2918290000
• Mol file: 105731-18-8.mol

Synonyms:3-(4-Hydroxy-2-methylphenyl)propionicacid methyl ester

Chemical Property of Benzenepropanoic acid, 4-hydroxy-2-methyl-, methyl ester

Chemical Property:

• Vapor Pressure: 0.000262mmHg at 25°C
• Refractive Index: 1.529
• Boiling Point: 313.9°C at 760 mmHg
• Flash Point: 131.8°C
• PSA: 46.53000
• Density: 1.119g/cm³
• LogP: 1.80620

Purity/Quality:

99% ^*data from raw suppliers

Methyl 3-(4-hydroxy-2-methylphenyl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, 4-hydroxy-2-methyl-, methyl ester

There total 8 articles about Benzenepropanoic acid, 4-hydroxy-2-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-benzyloxy-2-methyl-phenyl)-propionic acid methyl ester (728038-73-1) → methyl 3-(4-hydroxy-2-methylphenyl)propanoate (105731-18-8)

Guidance literature:

carbon palladium; In methanol;

Reference yield: 100.0%

3-(4-hydroxy-2-methylphenyl)acryl acid methyl ester (317319-05-4) → methyl 3-(4-hydroxy-2-methylphenyl)propanoate (105731-18-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃;

DOI:10.1016/S0960-894X(03)00207-5

Reference yield:

ethyl (2E)-3-{2-methyl-4-[(phenylmethyl)oxy]phenyl}-2-propenoate (638214-79-6) → methyl 3-(4-hydroxy-2-methylphenyl)propanoate (105731-18-8)

Guidance literature:

With hydrogen; 5% palladium over charcoal; In ethanol; for 15h; under 2068.65 Torr;

upstream raw materials:

methanol

3-(4-hydroxy-2-methylphenyl)propanoic acid

3-(4-hydroxy-2-methylphenyl)acryl acid methyl ester

4-bromo-3-methylphenol

Downstream raw materials:

3-(4-dimethylthiocarbamoyloxy-2-methyl-phenyl)-propionic acid methyl ester

3-{2-methyl-4-[5-(4-trifluoromethyl-phenyl)-thiophen-2-ylmethoxy]-phenyl}-propionic acid methyl ester

3-[4-(3-bromo-phenoxy)-2-methyl-phenyl]propionic acid methyl ester

3-[4-(3-bromo-5-methyl-phenoxy)-2-methyl-phenyl]propionic acid methyl ester

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS". Page/Page column 31-32. . Retrieved 2010/11/27.
• 2、 -. "BICYCLIC DERIVATIVES AS PPAR MODULATORS". Page/Page column 48. . Retrieved 2008/06/13.