[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

Base Information

Chemical Name:[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile
CAS No.:361534-75-0
Molecular Formula:C₂₂H₃₃NO₄Si
Molecular Weight:403.594
Hs Code.:

Synonyms:[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

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Chemical Property of [(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

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Technology Process of [(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

There total 4 articles about [(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 361534-73-8
(2S,4aS,6R,7S,8aR)-6-Hydroxymethyl-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 361534-75-0
[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

2: CH₂Cl₂ / 3 h / -78 - 0 °C

3: 1.33 g / molecular sieves 4 A / dimethylsulfoxide / 0.67 h / 80 °C

With 2,6-dimethylpyridine; 4 A molecular sieve; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol016355k

Reference yield:

: 1053634-48-2
(2S,4R,5S)-4-((2S,3S)-3-Hydroxymethyl-3-methyl-oxiranylmethyl)-2-phenyl-[1,3]dioxan-5-ol

: 361534-75-0
[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / PPTS / CH₂Cl₂ / 20 °C

2: 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

3: CH₂Cl₂ / 3 h / -78 - 0 °C

4: 1.33 g / molecular sieves 4 A / dimethylsulfoxide / 0.67 h / 80 °C

With 2,6-dimethylpyridine; 4 A molecular sieve; pyridinium p-toluenesulfonate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol016355k

Reference yield:

: {(2S,3S)-3-[(2S,4R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-ylmethyl]-2-methyl-oxiranyl}-methanol

: 361534-75-0
[(2S,4aS,6R,7S,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / TBAF / tetrahydrofuran / 20 °C

2: 100 percent / PPTS / CH₂Cl₂ / 20 °C

3: 2,6-lutidine / CH₂Cl₂ / 1 h / -78 °C

4: CH₂Cl₂ / 3 h / -78 - 0 °C

5: 1.33 g / molecular sieves 4 A / dimethylsulfoxide / 0.67 h / 80 °C

With 2,6-dimethylpyridine; 4 A molecular sieve; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol016355k