Technology Process of C14H12BrFO2
There total 1 articles about C14H12BrFO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-bromo-4-methoxy-benzene;
With
n-butyllithium;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
5-bromo-2-fluorobenzaldehyde;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 1h;
With
ammonium chloride;
In
tetrahydrofuran; ethyl acetate; toluene;
- Guidance literature:
-
With
triethylsilane; boron trifluoride diethyl etherate;
In
dichloromethane; acetonitrile;
at -40 ℃;
for 0.333333h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 0.33 h / -40 °C / Inert atmosphere
2.1: n-butyllithium / toluene; tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C
3.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane; acetonitrile / 0.33 h / -40 °C / Inert atmosphere
4.1: toluene-4-sulfonic acid / dichloromethane; methanol / 1 h / 50 °C
5.1: collidine / 20 h / 20 °C
6.1: Dess-Martin periodane / dichloromethane / 38 h / 20 °C
7.1: BAST / dichloromethane; tetrahydrofuran / 40 h / 20 °C / Cooling with water
8.1: hydrogen / palladium 10% on activated carbon / dichloromethane / 2 h / 20 °C / 4500.45 Torr
With
triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; hydrogen; Dess-Martin periodane; toluene-4-sulfonic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
