2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

Base Information

Chemical Name:2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide
CAS No.:1381766-55-7
Molecular Formula:C₂₅H₂₄N₂O₂
Molecular Weight:384.478
Hs Code.:

Synonyms:2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

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Chemical Property of 2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

Chemical Property:

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Technology Process of 2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

There total 3 articles about 2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1379481-73-8
2-iodo-N-(4-methoxyphenyl)-6-methylbenzamide

: 219605-52-4
2′-N,N-dimethylaminophenylacetylene

: 1381766-55-7
2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

Guidance literature:: 2-iodo-N-(4-methoxyphenyl)-6-methylbenzamide; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

2′-N,N-dimethylaminophenylacetylene; In N,N-dimethyl-formamide; at 80 - 85 ℃; Inert atmosphere;
DOI:10.1002/anie.201201640

Reference yield:

: 52107-92-3
2-iodo-6-methylbenzoyl chloride

: 1381766-55-7
2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 80 - 85 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1002/anie.201201640

Reference yield:

: 698-02-2
N,N-dimethyl-o-iodoaniline

: 1381766-55-7
2-((2-(dimethylamino)phenyl)ethynyl)-N-(4-methoxyphenyl)-6-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; diethyl ether; water / 0.17 h / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

3.2: 80 - 85 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; sodium hydroxide; In methanol; diethyl ether; water; N,N-dimethyl-formamide; 1.1: Sonogashira coupling / 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1002/anie.201201640