(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide

Base Information

• Chemical Name: (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide
• CAS No.: 180918-70-1
• Molecular Formula: C₁₃H₂₂N₂O₃S
• Molecular Weight: 286.395
• Mol file: 180918-70-1.mol

Synonyms:(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide

Chemical Property of (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide

There total 5 articles about (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.8%

(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide (180918-69-8) → (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (180918-70-1)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene; at 20 ℃; for 18h;

DOI:10.1021/jm0004289

Reference yield:

sulfuric acid (7664-93-9) + (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide (180918-69-8) → (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (180918-70-1)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminum dihydride; In tetrahydrofuran; methanol; toluene;

Reference yield:

4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid (100632-57-3) → (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (180918-70-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Et₃N / tetrahydrofuran / 1.5 h / -12 °C

2.1: Et₃N / tetrahydrofuran / 3 h / -12 °C

3.1: (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 3.5 h / -25 °C

3.2: 13.1 percent / diethanoloamine / tetrahydrofuran / 18 h / 20 °C

4.1: 66.8 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 18 h / 20 °C

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; toluene;

DOI:10.1021/jm0004289

upstream raw materials:

(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid

N-ethyl-γ-oxo-4-((methanesulfonyl)amino)benzenebutanamide

sulfuric acid

Downstream raw materials:

Trecetilide